This false claim originated from: viral social media post. government site. Genetics Genetics (specified analyses) are not evaluated in this study. Dysfunctional mitochondria predispose to oxidative stress and loss of cellular function and vitality. Remember to check the date when the fact-check you are reading was published before sharing it. As we reported last June 14, Bridle received a copy of a Japanese biodistribution study, which had been withheld from the public, as a result of a freedom of information request made to the Japanese government for data from Pfizer. It also was featured in a fact check by The Poynter Institutes Politifact,2 which pronounced Bridles findings as false after interviewing Dr. Drew Weissman,3 a UPenn scientist who is credited with helping to create the technology that enables the COVID mRNA vaccines to work. After the protein piece is made, the cell breaks down the instructions and gets rid of them. However, while the spike protein found in the virus is bad, the spike protein your body produces in response to the vaccine is far worse. If the damage is serious enough, uncontrolled cell death can occur, which in turn leaks mitochondrial DNA (mtDNA) into your bloodstream.13, Aside from being detected in cases involving acute tissue injury, heart attack and sepsis, freely circulating mtDNA has also been shown to contribute to a number of chronic diseases, including systemic inflammatory response syndrome or SIRS, heart disease, liver failure, HIV infection, rheumatoid arthritis and certain cancers.14 As explained in COVID-19: A Mitochondrial Perspective:15. An official website of the United States government. Manipulation of mitochondria by virus may lead to mitochondrial dysfunction and increased oxidative stress ultimately leading to loss of mitochondrial integrity and cell death , Mitochondrial fission enables removal of the damaged portion of a mitochondrion to be cleared by mitophagy (a special form of autophagy). Now, we have clear-cut evidence that the vaccines that make the cells in our deltoid muscles manufacture this protein, [we now know] the vaccine itself plus the protein gets into blood circulation. . Clipboard, Search History, and several other advanced features are temporarily unavailable. We thought the spike protein was a great target antigen; we never knew the spike protein itself was a toxin and was a pathogenic protein. Circulating SARS-CoV-2 Vaccine Antigen Detected in the Plasma of MRNA-1273 Vaccine Recipients. -. Prions are membrane proteins and when they misfold, they form crystals in the cytoplasm resulting in prion disease. The research examined thirteen young healthcare workers who had received the Moderna vaccine. As a public-health body safeguarding medicines in the European Union (EU), EMA only recommends approval of a vaccine for COVID-19 after a thorough evaluation demonstrating the same high . Its the first time ever scientists have been privy to seeing where these messenger RNA [mRNA] vaccines go after vaccination, Bridle told Pierson.10. Study of DS-5670a (COVID-19 Vaccine) in Japanese Healthy Adults and Elderly Subjects The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. , with maximum concentrations observed at 8-48 hours post-dose. SARS-CoV-2 MRNA Vaccine (BNT162, PF-07302048) 2.6.4 Summary of Pharmacokinetic Study. The signal decreased slowly during the first 72 hours and after 6 and 9 days the signals were further weakened to approximately levels of 18 and 7 times the signals obtained from animals injected with buffer control. The site is secure. Whats more, because the RNA code has been enriched with extra guanines (Gs) and cytosines (Cs), and configured as if its a human messenger RNA molecule ready to make protein by adding a polyA tail, the spike proteins RNA sequence in the vaccine looks as if it is part bacteria,17 part human18 and part viral at the same time. While all of this is highly problematic, there is help. It is a toxin that can cause damage in our body if it gets into circulation. The take-home message Kendrick delivers is that If you damage the lining of blood vessel walls, blood clots are far more likely to form. what does he mean by long time? The Ministry of Health, Labour and Welfare . Im the same I would like to find the original paper in Japanese if possible. Dr. Bridle, Associate Professor of Viral Immunology at the University of Guelph,received funding to develop a novel vaccine platform and is very much pro-vaccine. The biodistribution of BNT162b2 was examined as an alternative marker. EMA Reviews Pfizer Covid-19 Vaccine Animal Biodistribution Study Data. The assumption that vaccine developers have been working with is that the mRNA in the vaccines would . The objective of this guideline is to provide harmonised recommendations for the conduct of nonclinical biodistribution (BD) studies in the development of gene therapy (GT) products. We never knew the spike protein itself was a toxin and was a pathogenic protein. A Japanese study on the bio-distribution of Covid-19 products shows that mRNA travels to the ovaries and adrenal glands, suggesting why heartburn, blood clots, and other dangerous side. Find the original research and move on! Radioactivity was detected in most tissues from the first time point (0.25 h) and results support that injections site and the liver are the major sites of distribution. Is it a safe assumption that it stays in the shoulder muscle? Please Donate so that we can continue to bring you important updates concerning the Covid Virus Pandemic. Unable to load your collection due to an error, Unable to load your delegates due to an error. Since the mRNA in the vaccines has been modified to spew out very high amounts of spike protein (far greater than that of the actual virus), the risk of excessive buildup in the cytoplasm is high. Copyright 2023 Pandemic Timeline. After drying, the sections were exposed to a BAS imaging plate (FUJIFILM, Tokyo, Japan). The biodistribution study obtained by Bridle showed lipid nanoparticles from the vaccine did not stay in the deltoid muscle where they were injected as the vaccine's developers claimed would happen, but circulated throughout the body and accumulated in large concentrations in organs and tissues, including the spleen, bone marrow, liver, adrenal Even my doctor, who is against it, could not tell me public sources. Information on the biodistribution (BD) of cell therapy products (CTPs) is essential for prediction and assessment of their efficacy and toxicity profiles in non-clinical and clinical studies. Bipolar disorder and complementary medicine: current evidence, safety issues, and clinical considerations. Many different unusual, prolonged, or delayed reactions have been reported, and often these are more pronounced after the second shot. Confidential pfizer research document Translated from Japanese to English. Your most powerful anticlotting system is your glycocalyx, the protective layer of glycoproteins that lines your blood vessels. The mean concentrations and tissue distribution pattern were broadly similar between the sexes. Arthritis Care Res (Hoboken). Once in your blood circulation, the spike protein binds to platelet receptors and the cells that line your blood vessels. Prior to the study's disclosure, the public was led to believe by regulators and vaccine developers that the . Next, LPP formulated with mRNA encoding luciferase as a model. All of these risk factors have something in common: Theyre all associated with mitochondrial dysfunction. This is a problem, because rather than instructing your muscle cells to produce the spike protein (the antigen that triggers antibody production), spike protein is actually being produced inside your blood vessel walls and various organs, where it can do a great deal of damage. Careers. Bridle also cites recent research showing the spike protein remained in the bloodstream of humans for 29 days. Time-restricted eating will upregulate autophagy, while sauna therapy, which upregulates heat shock proteins, will help refold misfolded proteins and also tag damaged proteins and target them for removal. The more we learn about the COVID-19 vaccines, the worse they look. We thought the spike protein was a great target antigen; we never knew it was a toxin. I am giving you the technical version so you can see for yourself the actual data reviewed by EMA. The effective dose was 0.0705 mSv/MBq. Vaccine Researcher Admits Big Mistake, Says Spike Protein Is Dangerous Toxin.. No safety pharmacology studies were conducted with BNT162b2. Not believing the outcome of my research, I called for help from my PhD friends at Penn State in the Materials Research Institute. See this image and copyright information in PMC. and when exactly? It was a pre-clinical biodistribution study. Low levels of radioactivity were detected in most tissues, with the greatest levels in plasma observed 1-4 hours post-dose. Number of biodistribution (BD) studies in cell-based therapeutic product as of September 2018, Implementation status of clinical biodistribution, Implementation status of clinical biodistribution by formulation in locally administered product group as, Trends of cell quantification using Alu-qPCR methods. Read summaries of real world examples of proejcts completed by SGW Designworks. The liver expression is also supportive of the data from the rat PK study and the findings in the rat repeat-dose toxicological study showing reversible liver vacuolation and increased GGT levels. The bioanalysis methods appear to be adequate. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). And, since the spike protein doesnt enter into the membrane of the cell, theres a high risk that it can become problematic if indeed it works like a prion. For the first time ever, the Japanese Regulatory Agency recently gave Bridle and several international collaborators access to a study called the Bio-Distribution Study. The groundbreaking research presents scientists with a more reliable understanding of where COVID-19 messenger RNA (mRNA) vaccines travel in the body after being injected. It can cause damage in our body if it gets into circulation The spike protein on its own is almost entirely responsible for the damage to the cardiovascular system, if it gets into circulation.. The biodistribution study obtained by Bridle showed lipid nanoparticles from the vaccine did not stay in the deltoid muscle where they were injected as the vaccine's developers claimed would happen, but circulated throughout the body and accumulated in large concentrations in organs and tissues, including the spleen, bone marrow, liver, adrenal Together with international scientists, he requested access to the "biodistribution study" from the Japanese regulatory agency that is labeled "Pfizer Confidential." People are now receiving injections with an mRNA gene therapy-based vaccine, which produces the SARS-CoV-2 spike protein in their cells, and the vaccine may be also delivering the mRNA and producing spike protein in unintended organs and tissues (which may include ovaries)., The assumption that vaccine developers have been working with is that the mRNA in the vaccines (or DNA in the case of Johnson & Johnson and AstraZenecas vaccines) would primarily remain in and around the vaccination site, i.e., your deltoid muscle, with a small amount draining into local lymph nodes.8, Pfizers data, however, show this isnt the case at all. Human organ radiation dosimetry is shown in Table 2. ), o determined the biodistribution of a surrogate luciferase modRNA formulated with a LNP with identical lipid composition used in BNT162b2 (mouse study). In 2020, Bridle was awarded a $230,000 government grant for research on COVID vaccine development. As explained by Bridle, when that happens, one of several things can occur: Importantly, people who have been vaccinated against COVID-19 absolutely should not donate blood, seeing how the vaccine and the spike protein are both transferred. sharing sensitive information, make sure youre on a federal PLoS One. Methods: This is a retrospective single-center study in 23 patients with COVID-19-induced ARDS. It also modulates the adhesion of platelets to the endothelium. Image . Data were . Why are these questions surfacing now? As noted by Mikovits, remedies to the maladies that might develop post-vaccination include: From my perspective, I believe the best thing you can do is to build your innate immune system. Biodistribution of the component of an mRNA vaccine following administration may influence the safety and efficacy of vaccine. Bridle believes there should be more reliable evidence before vaccinating kids, and doctors from Johns Hopkins and the University of California San Francisco agree. Background The viral load and tissue distribution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain important questions. The bottom line is mRNA Covid vaccines are still considered experimental by the FDA as research continues to be done. This not only leads to impaired MAVS [mitochondrial antiviral signaling] response but also aggravates inflammation and cell death.. In the current work, we aimed to investigate the impact of formulation type on biodistribution profile . Bethesda, MD 20894, Web Policies According to this study, there was no difference in ovarian function between those who were infected with the Covid-19 and those who were not. Please send me all info on any new updates. Explanation: We deem this post as disinformation when it is claimed that the spike protein attacks the ovaries, the neurological system, and other organs. (a) Number of cell-based therapeutic product in cell formulation and number of cell-based therapeutic product with or without biodistribution study in (b) cell-suspension CTP and (c) tissue or cell-sheet CTP (refer to Supplementary Table1). Number of biodistribution (BD) studies in cell-based therapeutic product as of September 2018 in comparison among (a) local or systemic administration product, (b) commercialized or product in clinical phases, (c) biodistribution measurement modalities, (d) clinical phases of development, (e) used animal species and (f) measurement modalities and biodistribution study duration (refer to Supplementary Table1). https://www.regulations.gov/docket/FDA-2021-P-0521/document. 8.7. Stem Cells Transl Med. In her paper, Worse Than The Disease: Reviewing Some Possible Unintended Consequences of mRNA Vaccines Against COVID-19, published in the International Journal of Vaccine Theory, Practice and Research in collaboration with Dr. Greg Nigh,16 Seneff explains why the unnatural spike protein is so problematic. The research,4,5 previously unseen, demonstrates a huge problem with all COVID-19 vaccines. Brief Summary: The purpose of this study is to evaluate the biodistribution, safety and tolerability of a single dose of [18F]GTP1 as a tau targeted radiopharmaceutical in healthy Japanese participants. which is it, did they or did they now know that the spike protein was a toxin/pathogenic for a long time? In a separate study, mice received IV injection of an imaging dose of [ 52 Mn]MnCl 2, followed by in vivo imaging by positron emission tomography (PET) and ex vivo biodistribution. Please enable it to take advantage of the complete set of features! What does this startling discovery mean for blood donations? After spending 20 hours of research, I found there are. This is about as diabolical as it gets. When I looked up study PF-07302048 (BNT162 RNA-Based COVID-19 Vaccines) Protocol C4591001, I found no mention of biodistribution, only the following stated on page 72/147: However, the EMA referenced study PF-07302048 and its biodistribution results as below: Biodistribution of a LNP-formulated luciferase surrogate reporter: (Meaning they substituted a luciferine protein in place of the actual mRNA part of the vaccine. We now know spike protein gets into circulation. The biodistribution was also studied in rats using radiolabeled LNP and luciferase modRNA (study 185350).. Bookshelf It has been one of the hardest blogs for me to write and why you did not receive a blog last week! Dr. Bret Weinstein, Dr. Robert Malone, Steve Kirsch 2015;43(1):115125. Until recently, the opinion has been that these vaccines function like traditional vaccines and remain near the injection site. That is, luciferase RNA inclusion LNP was intramuscularly administered to the left and right hind limbs of mice at a dose of 1 g RNA (2 g RNA in total). In Japan, 10 fatal cases (five men and women) have been reported to date. HHS Vulnerability Disclosure, Help S1A). Please read and agree to the disclaimer before watching this video.. SARS-COV-2 Spikes in Ovaries from Pfizer-BioNTech Vaccine?There has been some uncertaint. Learn more 208-391-4000 This is a nonprofit education and research site. Nothing whatsoever on this site is monetized, not even the Amazon links. I therefore claim fair use of materials featured here. To find out what is new, check out the above sidebar item, Recently Modified Posts. New posts are added according to date of event in keeping with the timeline theme, NOT the date when they are created. Material is often added to existing posts as well, as more is learned about an event. To make best use of this site, consider using the tags, categories, and search box. Many posts also have a See also, on this site list. For more details about the purpose and style of this site, please see the About page. In the case of the Pfizer COVID mRNA vaccine, these newly revealed documents raise additional questions about both the genotoxicity and reproductive toxicity risks of this product. o or the biodistribution of a [3H]-Labelled Lipid Nanoparticle-mRNA Formulation (rat study). Accessibility In what organs can you find the vaccine? Stephanie Seneff, Ph.D., and Judy Mikovits, Ph.D. . In related news, Dr. Malcolm Kendrick posted an article11 on his website June 3, 2021, in which he discusses the links between the SARS-CoV-2 spike protein and vasculitis, a medical term referring to inflammation (itis) in your vascular system, which is made up of your heart and blood vessels. I thought this would be an easy blog to write, cut and dry. The attack causes damage to the lining, which results in inflammation. Indeed, for many months, weve known that the worst symptoms of severe COVID-19, blood clotting problems in particular, are caused by the spike protein of the virus. People will continue to gather evidence supporting the vaccine, and people will continue to gather evidence against the vaccine. 2018;7(1):7886. At first glance, this information seems relatively straightforward. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Write, cut and dry mRNA vaccine following administration may influence biodistribution study japan safety efficacy. Near the injection site most powerful anticlotting system is your glycocalyx, the opinion has been evaluated by the federal. 8-48 hours post-dose a pathogenic protein 2.6.4 Summary of Pharmacokinetic study Donate so that we can continue gather. 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